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<body xmlns="http://www.w3.org/1999/xhtml">Programmed cell death (PCD) is an essential cellular mechanism that is evolutionary conserved, mediated through various pathways and acts by integrating different stimuli. Many diseases such as neurodegenerative diseases and cancers are found to be caused by, or associated with, regulations in the cell death pathways. Yeast Saccharomyces cerevisiae, is a unicellular eukaryotic organism that shares with human cells components and pathways of the PCD and is therefore used as a model organism. Boolean modeling is becoming promising approach to capture qualitative behavior and describe essential properties of such complex networks. Here we present large literature-based and to our knowledge first Boolean model that combines pathways leading to apoptosis (a type of PCD) in yeast. Analysis of the yeast model confirmed experimental findings of anti-apoptotic role of Bir1p and pro-apoptotic role of Stm1p and revealed activation of the stress protein kinase Hog proposing the maximal level of activation upon heat stress. In addition we extended the yeast model and created an in silico humanized yeast in which human pro- and anti-apoptotic regulators Bcl-2 family and Valosin-contain protein (VCP) are included in the model. We showed that accumulation of Bax in silico humanized yeast shows apoptotic markers and that VCP is essential target of Akt Signaling. The presented Boolean model provides comprehensive description of yeast apoptosis network behavior. Extended model of humanized yeast gives new insights of how complex human disease like neurodegeneration can initially be tested.</body>
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<vCard:Family>Helikar</vCard:Family>
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<vCard:EMAIL>thelika@unmc.edu</vCard:EMAIL>
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<vCard:Orgname>University of Nebraska - Lincoln</vCard:Orgname>
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<p>Hydroxide peroxide</p></body>
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<p>Chemical input (external species)</p></body>
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<p>Abnormal telomerase (external species)</p></body>
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<qual:qualitativeSpecies metaid="b73c3e1c-d310-4d77-b72e-5b5cda67cfeb" qual:compartment="extracellular" qual:constant="true" qual:id="S_36" qual:name="Stress">
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<p>Mating pheromone (external species)</p></body>
</notes>
<annotation>
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<qual:qualitativeSpecies metaid="_57819a13-ded6-4d06-a4d0-93335aaa0d6b" qual:compartment="extracellular" qual:constant="true" qual:id="S_51" qual:name="CU2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Copper ion</p></body>
</notes>
<annotation>
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<dcterms:W3CDTF>2017-07-17T10:41:06Z</dcterms:W3CDTF>
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<qual:qualitativeSpecies metaid="d01243e4-692b-42c9-8969-43064ffddd82" qual:compartment="extracellular" qual:constant="true" qual:id="S_53" qual:name="RedActinDyn">
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<qual:qualitativeSpecies metaid="f4311b6d-97ab-4b1f-a0c3-61961a55e6d9" qual:compartment="extracellular" qual:constant="true" qual:id="S_58" qual:name="CPR3">
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<dcterms:W3CDTF>2018-04-14T18:37:30Z</dcterms:W3CDTF>
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<qual:qualitativeSpecies metaid="_0205b193-e9bb-43c7-b1c4-3772548afe74" qual:compartment="extracellular" qual:constant="true" qual:id="S_59" qual:name="Heat">
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<rdf:Description rdf:about="#_0205b193-e9bb-43c7-b1c4-3772548afe74">
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<dcterms:W3CDTF>2017-07-18T16:05:24Z</dcterms:W3CDTF>
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<qual:qualitativeSpecies metaid="f5c60362-740d-4aa9-adf3-28f608bb435e" qual:compartment="extracellular" qual:constant="true" qual:id="S_63" qual:name="Adozelesin">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Drug input (external species)</p></body>
</notes>
<annotation>
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<qual:qualitativeSpecies metaid="_1790c921-6ec3-43a7-982b-86abb0c68654" qual:compartment="extracellular" qual:constant="true" qual:id="S_66" qual:name="Salt">
<annotation>
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<qual:qualitativeSpecies metaid="bafbe5ff-0754-418c-96b9-e7014bd7dfae" qual:compartment="cytosol" qual:constant="false" qual:id="S_1" qual:initialLevel="0" qual:maxLevel="1" qual:name="NMA111-CYT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Nuclear mediator of apoptosis in cytososl<div>UniProt AccessionID: P53920</div></p></body>
</notes>
<annotation>
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<bqbiol:isDescribedBy>
<rdf:Bag>
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<qual:qualitativeSpecies metaid="_1bb9257e-685f-45e9-9b71-b45d3fa6f929" qual:compartment="cytosol" qual:constant="false" qual:id="S_2" qual:initialLevel="0" qual:maxLevel="1" qual:name="ESP1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Separase protein<div>UniProt AccessionID: Q03018</div></p></body>
</notes>
<annotation>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
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<qual:qualitativeSpecies metaid="f52a7a4b-2ec0-464b-bb5c-328f721fd9a6" qual:compartment="cytosol" qual:constant="false" qual:id="S_3" qual:initialLevel="0" qual:maxLevel="1" qual:name="RPD3">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Reduced potassium dependency<div>UniProt AccessionID: P32561</div></p></body>
</notes>
<annotation>
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<rdf:Bag>
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<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitosis entry checkpoint<div>UniProt AccessionID: P38111</div></p></body>
</notes>
<annotation>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16079294"/>
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<qual:qualitativeSpecies metaid="_6c66771a-5e12-4969-bb12-5e2a80af4139" qual:compartment="cytosol" qual:constant="false" qual:id="S_5" qual:initialLevel="0" qual:maxLevel="1" qual:name="SLT2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Syntaxin (SYN8)<div>UniProt AccessionID: Q00772</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_6c66771a-5e12-4969-bb12-5e2a80af4139">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-18T16:05:24Z</dcterms:W3CDTF>
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
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</rdf:RDF>
</annotation>
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<qual:qualitativeSpecies metaid="_9faecd76-7ac4-4892-8c06-3bb4f19a4965" qual:compartment="cytosol" qual:constant="false" qual:id="S_6" qual:initialLevel="0" qual:maxLevel="1" qual:name="MAPK">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Map kinase cascade<div>UniProt AccessionID: B3LT78</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
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<qual:qualitativeSpecies metaid="e1e3e130-05c9-4a7d-822b-b4ef8e800f77" qual:compartment="cytosol" qual:constant="false" qual:id="S_7" qual:initialLevel="0" qual:maxLevel="1" qual:name="STE20-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription">Sterile in nucleus</span></p><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.399999618530273px; background-color: rgb(255, 255, 255);">UniProt AccessionID: Q03497</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#e1e3e130-05c9-4a7d-822b-b4ef8e800f77">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="a2f5d7c9-9d97-49fd-9e05-db979628f47d" qual:compartment="cytosol" qual:constant="false" qual:id="S_8" qual:initialLevel="0" qual:maxLevel="1" qual:name="MDV1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitochondrial Division<div>UniProt AccessionID: P47025</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#a2f5d7c9-9d97-49fd-9e05-db979628f47d">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="aedd7e87-c218-4b22-9930-0148c6dbbb8f" qual:compartment="cytosol" qual:constant="false" qual:id="S_9" qual:initialLevel="0" qual:maxLevel="1" qual:name="STE20-CYT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Sterile in cytosol<div>UniProt AccessionID: Q03497</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#aedd7e87-c218-4b22-9930-0148c6dbbb8f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_317790c6-0cea-4abb-b77f-6139419f6b47" qual:compartment="cytosol" qual:constant="false" qual:id="S_11" qual:initialLevel="0" qual:maxLevel="1" qual:name="POR1-2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Arial, Verdana" size="2">Porin</font><div><font face="Arial, Verdana" size="2">UniProt AccessionID: P04840, UniProt AccessionID: P40478</font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_317790c6-0cea-4abb-b77f-6139419f6b47">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T21:00:49Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_51140518-60f5-402a-acc5-38246c9a92de" qual:compartment="cytosol" qual:constant="false" qual:id="S_12" qual:initialLevel="0" qual:maxLevel="1" qual:name="CDC6">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font size="2">Cell division Cycle</font><div><font size="2">UniProt AccessionID:&nbsp;P09119</font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_51140518-60f5-402a-acc5-38246c9a92de">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12006651"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_5f75bd7c-d05c-4d48-821a-c8b7e3ff0c91" qual:compartment="cytosol" qual:constant="false" qual:id="S_13" qual:initialLevel="0" qual:maxLevel="1" qual:name="HOG1-Dep">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>HOG1 dependent genes<div>UniProt AccessionID: P32485</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_5f75bd7c-d05c-4d48-821a-c8b7e3ff0c91">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_58a583cf-5db5-4c85-b37f-47100b215ac1" qual:compartment="cytosol" qual:constant="false" qual:id="S_15" qual:initialLevel="0" qual:maxLevel="1" qual:name="EMC4">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>ER membrane protein complex<div>UniProt AccessionID: P53073</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_58a583cf-5db5-4c85-b37f-47100b215ac1">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_2b2c633c-972b-4365-a3b7-359094189fcb" qual:compartment="cytosol" qual:constant="false" qual:id="S_16" qual:initialLevel="0" qual:maxLevel="1" qual:name="H2B">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Histon 2B<div>UniProt AccessionID:</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_2b2c633c-972b-4365-a3b7-359094189fcb">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:9348289"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17244531"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15381687"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17052455"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="b493b768-b69e-4e2d-ac07-2e35eff3d5a6" qual:compartment="cytosol" qual:constant="false" qual:id="S_17" qual:initialLevel="0" qual:maxLevel="1" qual:name="MT-Frag">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitochondria fragmentation</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#b493b768-b69e-4e2d-ac07-2e35eff3d5a6">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19194512"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_219900f4-dad1-4be8-b79a-6b8670925dcc" qual:compartment="cytosol" qual:constant="false" qual:id="S_18" qual:initialLevel="0" qual:maxLevel="1" qual:name="CDC48">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font size="2" style="font-size: 10pt;">Cell division cycle</font><div><font size="2">UniProt AccessionID: P25694<br/></font><div style="font-size: 10pt;"><br/></div></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_219900f4-dad1-4be8-b79a-6b8670925dcc">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="d09c8326-d14f-4081-9122-2c47e9288569" qual:compartment="cytosol" qual:constant="false" qual:id="S_19" qual:initialLevel="0" qual:maxLevel="1" qual:name="SOD1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Superoxide dismutase<div>Uniprot AccessionID: P00445</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#d09c8326-d14f-4081-9122-2c47e9288569">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_85d2fb02-522e-4e85-bb97-bbb357f97328" qual:compartment="cytosol" qual:constant="false" qual:id="S_21" qual:initialLevel="0" qual:maxLevel="1" qual:name="MMI1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Translation machinery associated<div>UniProt AccessionID: P35691</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_85d2fb02-522e-4e85-bb97-bbb357f97328">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="c08b17fa-bf68-40d9-b653-86de89dfab95" qual:compartment="cytosol" qual:constant="false" qual:id="S_22" qual:initialLevel="0" qual:maxLevel="1" qual:name="CytC-MT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>CytochromC in mitochondria<div>UniProt AccessionID: P07143</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#c08b17fa-bf68-40d9-b653-86de89dfab95">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:18321989"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12181332"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_10568278-cdd5-4681-b679-97f8408a1651" qual:compartment="cytosol" qual:constant="false" qual:id="S_23" qual:initialLevel="0" qual:maxLevel="1" qual:name="PKA">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Protein kinase A<div>UniProt ID:&nbsp;<a style="color: rgb(64, 148, 180); line-height: 20.08px; font-family: Verdana, Arial, sans-serif; font-size: 13.05px; text-decoration: none; border-bottom-width: 0px; cursor: pointer; background-color: rgb(255, 255, 255);" href="http://www.uniprot.org/uniprot/P12370">P12370</a></div><div>Gene Name:&nbsp;<a style="color: rgb(100, 42, 143); line-height: 17.99px; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; white-space: nowrap; background-color: rgb(213, 222, 227);" href="http://www.ncbi.nlm.nih.gov/gene/34284" ref="ordinalpos=4&amp;ncbi_uid=34284&amp;link_uid=34284"><span class="highlight">Pka</span>-C1</a></div><div>Gene ID:&nbsp;<span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);">34284</span></div><div><span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);"></span>&nbsp;</div><div><span style="color: rgb(87, 87, 87); line-height: 16.19px; font-family: arial, helvetica, clean, sans-serif; font-size: 11.69px; background-color: rgb(213, 222, 227);"><table style="width: 723pt; border-collapse: collapse;" border="0" cellSpacing="0" cellPadding="0" width="964">\r\n <colgroup><col style="width: 723pt; mso-width-source: userset; mso-width-alt: 30848;" width="964">\r\n <tbody><tr style="height: 15pt;" height="20">\r\n\r\n <td style="border: 0px black; width: 723pt; height: 15pt; background-color: transparent;" class="xl65" height="20" width="964"><font color="#000000" size="3" face="Calibri">protein\r\n kinase, cAMP-dependent, catalytic, alpha</font></td>\r\n\r\n </tr>\r\n</tbody></table></span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_10568278-cdd5-4681-b679-97f8408a1651">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_8c1cabc0-57cd-401d-ae07-44c4401f787f" qual:compartment="cytosol" qual:constant="false" qual:id="S_24" qual:initialLevel="0" qual:maxLevel="1" qual:name="PTP3">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription">Protein tyrosine phosphatase</span></p><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.399999618530273px; background-color: rgb(255, 255, 255);">UniProt AccessionID: P40048</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_8c1cabc0-57cd-401d-ae07-44c4401f787f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-17T15:49:48Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_46570f4a-8659-402c-8b6c-8e879dd58f3b" qual:compartment="cytosol" qual:constant="false" qual:id="S_25" qual:initialLevel="0" qual:maxLevel="1" qual:name="DRE2_TAH18">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Dre2-TAH18 complex</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_46570f4a-8659-402c-8b6c-8e879dd58f3b">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="deb1b353-62e9-485d-a3a4-cda5fe61b57b" qual:compartment="cytosol" qual:constant="false" qual:id="S_26" qual:initialLevel="0" qual:maxLevel="1" qual:name="Protosom">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Protosom complex</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#deb1b353-62e9-485d-a3a4-cda5fe61b57b">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12006651"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_56c14cc9-b664-4fcd-baa7-de6b28e2cced" qual:compartment="cytosol" qual:constant="false" qual:id="S_27" qual:initialLevel="0" qual:maxLevel="1" qual:name="SVF1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font color="#575757" face="arial, helvetica, clean, sans-serif"><span style="font-size: 11.199999809265137px; line-height: 15.399999618530273px; white-space: nowrap;">Survival factor</span></font><div><font color="#575757" face="arial, helvetica, clean, sans-serif"><span style="font-size: 11.199999809265137px; line-height: 15.399999618530273px; white-space: nowrap;">UniProt AccessionID: Q05515</span></font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_56c14cc9-b664-4fcd-baa7-de6b28e2cced">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_5e799501-f4a9-44b2-b4f7-134f50569f0c" qual:compartment="cytosol" qual:constant="false" qual:id="S_28" qual:initialLevel="0" qual:maxLevel="1" qual:name="CytC-CYT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>CytochromC in cytososl<div>UniProt AccessionID:&nbsp;<a href="http://www.uniprot.org/uniprot/P08574" style="font-size: small; text-decoration: none; font-family: sans-serif; background-color: rgb(255, 255, 255);">P08574</a></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_5e799501-f4a9-44b2-b4f7-134f50569f0c">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="b3e31db3-8137-4c4b-b5e8-8a62eba59500" qual:compartment="cytosol" qual:constant="false" qual:id="S_29" qual:initialLevel="0" qual:maxLevel="1" qual:name="Tat-D">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>3' &gt;&gt; 5' exonuclease and endonuclease<div>UniProt AccessionID: P34220</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#b3e31db3-8137-4c4b-b5e8-8a62eba59500">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15657035"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_9086bed7-1f43-46f3-8e1e-82e932a1dba9" qual:compartment="cytosol" qual:constant="false" qual:id="S_30" qual:initialLevel="0" qual:maxLevel="1" qual:name="FIS1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><font face="Arial, Verdana" size="2">Mitochondrial Fission</font><div><font face="Arial, Verdana" size="2">UniProt AccessionID: P40515</font></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_9086bed7-1f43-46f3-8e1e-82e932a1dba9">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_91ac5da7-dea4-467e-a544-c5bee968f455" qual:compartment="cytosol" qual:constant="false" qual:id="S_31" qual:initialLevel="0" qual:maxLevel="1" qual:name="RAS2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Homologous to RAS proto-oncogene<div>UniProt AccessionID: P01120</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_91ac5da7-dea4-467e-a544-c5bee968f455">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14673167"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="d01ad0f8-88b1-474a-9363-36bcde01ba82" qual:compartment="cytosol" qual:constant="false" qual:id="S_33" qual:initialLevel="0" qual:maxLevel="1" qual:name="MCD1-MT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitotic chromosome determinant in mitochondria<div>UniProt AccessionID:&nbsp;</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#d01ad0f8-88b1-474a-9363-36bcde01ba82">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_61ce0ea5-f26e-471b-a854-5286c80911e9" qual:compartment="cytosol" qual:constant="false" qual:id="S_35" qual:initialLevel="0" qual:maxLevel="1" qual:name="NUC1-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription">Nuclease 1 in nucleus</span></p><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.399999618530273px; background-color: rgb(255, 255, 255);">UniProt AccessionID: P08466</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_61ce0ea5-f26e-471b-a854-5286c80911e9">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17244531"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_89eef961-4cac-4d07-be38-2c1735f38bb7" qual:compartment="cytosol" qual:constant="false" qual:id="S_37" qual:initialLevel="0" qual:maxLevel="1" qual:name="SDP1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Stress-inducible dual specificity phosphatase<div>UniProt AccessionID: P40479</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_89eef961-4cac-4d07-be38-2c1735f38bb7">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-18T16:05:24Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_58de0424-3252-4a3f-a238-939e22bff3b0" qual:compartment="cytosol" qual:constant="false" qual:id="S_38" qual:initialLevel="0" qual:maxLevel="1" qual:name="DesCyclinCCDK8">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Destruction of cylinC/CDCk8</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_58de0424-3252-4a3f-a238-939e22bff3b0">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16387872"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_502d3c82-25e8-43ac-98a3-90ffd3ff53dd" qual:compartment="cytosol" qual:constant="false" qual:id="S_39" qual:initialLevel="0" qual:maxLevel="1" qual:name="Apoptosis">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Cell death</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_502d3c82-25e8-43ac-98a3-90ffd3ff53dd">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T18:58:54Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17881727"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19250922"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16608876"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:18355271"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17822411"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_8b92bee3-3d02-415c-b53c-ed222f3bc22a" qual:compartment="cytosol" qual:constant="false" qual:id="S_40" qual:initialLevel="0" qual:maxLevel="1" qual:name="BIR1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Baculoviral IAP repeat-containing protein 1<div>UniProt AccessionID:&nbsp;</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_8b92bee3-3d02-415c-b53c-ed222f3bc22a">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:56:06Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16608876"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="c2d955b1-b7d1-4076-8655-330e006c461f" qual:compartment="cytosol" qual:constant="false" qual:id="S_41" qual:initialLevel="0" qual:maxLevel="1" qual:name="HOS3">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>HDA one similar<div>UniProt AccessionID: Q02959</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#c2d955b1-b7d1-4076-8655-330e006c461f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_4f9e0770-eea4-4628-9f1b-ee5cad012182" qual:compartment="cytosol" qual:constant="false" qual:id="S_42" qual:initialLevel="0" qual:maxLevel="1" qual:name="ROS-MT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Reactive oxygen species in mitochondria</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_4f9e0770-eea4-4628-9f1b-ee5cad012182">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-05-19T14:00:19Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20587024"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="ecad6996-866d-4a85-9cbe-480cae711a0a" qual:compartment="cytosol" qual:constant="false" qual:id="S_43" qual:initialLevel="0" qual:maxLevel="1" qual:name="DNA-Frag">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>DNA fragmentation</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#ecad6996-866d-4a85-9cbe-480cae711a0a">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:58:36Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15657035"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11514626"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="a9b7a686-f892-4d04-a2c3-04761636c78f" qual:compartment="cytosol" qual:constant="false" qual:id="S_44" qual:initialLevel="0" qual:maxLevel="1" qual:name="ROS-CYT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Reactive oxygen species in cytososl</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#a9b7a686-f892-4d04-a2c3-04761636c78f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:58:36Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:18321989"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:18586032"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16387872"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:6327067"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14718573"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:12244097"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_9bf32088-3edc-4462-af10-78f4ca05792d" qual:compartment="cytosol" qual:constant="false" qual:id="S_45" qual:initialLevel="0" qual:maxLevel="1" qual:name="AIF1-MT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Apoptosis-inducing factor in mitochondria<div>UniProt AccessionID:&nbsp;<a href="http://www.uniprot.org/uniprot/P52923" style="text-decoration: none; font-family: sans-serif; font-size: small; background-color: rgb(255, 255, 255);">P52923</a></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_9bf32088-3edc-4462-af10-78f4ca05792d">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="b638de12-f5f7-4231-a9d0-16dcfae2145a" qual:compartment="cytosol" qual:constant="false" qual:id="S_46" qual:initialLevel="0" qual:maxLevel="1" qual:name="CAMP">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Cyclic adenosine monophosphate<div>UniProt AccessionID:</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#b638de12-f5f7-4231-a9d0-16dcfae2145a">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14673167"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_1445fe57-ff1c-4b80-91c1-a624dfdaa2e4" qual:compartment="cytosol" qual:constant="false" qual:id="S_47" qual:initialLevel="0" qual:maxLevel="1" qual:name="MSN2-4">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Multicopy suppressor of SNF1 mutation<div>UniProt AccessionID:&nbsp;</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_1445fe57-ff1c-4b80-91c1-a624dfdaa2e4">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_0778291e-ae19-4274-95b3-1762f2aff424" qual:compartment="cytosol" qual:constant="false" qual:id="S_49" qual:initialLevel="0" qual:maxLevel="1" qual:name="STM1-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Translation initiation factor (TIF3) in nucleus<div><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span style="line-height: 14.399999618530273px;">UniProt AccessionID: P39015</span></p></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_0778291e-ae19-4274-95b3-1762f2aff424">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11514626"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_6bb9b4bd-91c9-4ee2-9b64-d62c0f1178c0" qual:compartment="cytosol" qual:constant="false" qual:id="S_50" qual:initialLevel="0" qual:maxLevel="1" qual:name="MCD1-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitotic chromosome determinant in nucleus<div>UniProt AccessionID: Q12158</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_6bb9b4bd-91c9-4ee2-9b64-d62c0f1178c0">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:18321989"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="efbc3dc4-e4c4-477b-aa94-da9aaf225e08" qual:compartment="cytosol" qual:constant="false" qual:id="S_52" qual:initialLevel="0" qual:maxLevel="1" qual:name="PTP2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Protein tyrosine phosphatase<div>UniProt AccessionID: P29461</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#efbc3dc4-e4c4-477b-aa94-da9aaf225e08">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-18T16:05:24Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="facc9c3c-ef7a-46c6-9af3-b6b11a01beee" qual:compartment="cytosol" qual:constant="false" qual:id="S_54" qual:initialLevel="0" qual:maxLevel="1" qual:name="YCA1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>MetaCAspase<div>UniProt AccessionID: Q08601</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#facc9c3c-ef7a-46c6-9af3-b6b11a01beee">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:56:34Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:19250922"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16079294"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14718573"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11983181"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="dc70a4af-8e83-4041-b0df-b36ab9c8325f" qual:compartment="cytosol" qual:constant="false" qual:id="S_55" qual:initialLevel="0" qual:maxLevel="1" qual:name="NDI1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>NADH dehydrogenase internal<div>UniProt AccessionID: P32340</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#dc70a4af-8e83-4041-b0df-b36ab9c8325f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-05-19T14:00:19Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_53f8489d-b3d8-4a9e-93f3-70b1565b5aba" qual:compartment="cytosol" qual:constant="false" qual:id="S_56" qual:initialLevel="0" qual:maxLevel="1" qual:name="SRO7">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Suppressor of rho3<div>UniPro AccessionID: A6ZWS5</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_53f8489d-b3d8-4a9e-93f3-70b1565b5aba">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_168c6318-c0a7-4081-bb6d-3b4a186ae99e" qual:compartment="cytosol" qual:constant="false" qual:id="S_57" qual:initialLevel="0" qual:maxLevel="1" qual:name="KAP123">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>KaryoPherin<div>UniProt AccessionID: P40069</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_168c6318-c0a7-4081-bb6d-3b4a186ae99e">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17244531"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_89f49df0-fce5-4b24-b6dc-bf324de1bb12" qual:compartment="cytosol" qual:constant="false" qual:id="S_60" qual:initialLevel="0" qual:maxLevel="1" qual:name="STM1-CYT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Translation initiation factor (TIF3) in cytososl<div><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span style="line-height: 14.399999618530273px;">UniProt AccessionID: P39015</span></p></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_89f49df0-fce5-4b24-b6dc-bf324de1bb12">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_809011c0-cdbd-4cfa-9f3b-b376d498907a" qual:compartment="cytosol" qual:constant="false" qual:id="S_61" qual:initialLevel="0" qual:maxLevel="1" qual:name="RLM1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Resistance to lethality of MKK1P386 overexpression<div>UniProt AccessionID: A6ZWG2</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_809011c0-cdbd-4cfa-9f3b-b376d498907a">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-18T16:05:24Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="c787596d-a77c-4009-9681-a3e46ab630da" qual:compartment="cytosol" qual:constant="false" qual:id="S_62" qual:initialLevel="0" qual:maxLevel="1" qual:name="AdenylateCyclase">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Lyase enzyme</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#c787596d-a77c-4009-9681-a3e46ab630da">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14673167"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:8106517"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="fcf49745-88e3-40e2-99cd-c9b7b890ef41" qual:compartment="cytosol" qual:constant="false" qual:id="S_64" qual:initialLevel="0" qual:maxLevel="1" qual:name="TOR1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Target of rapamycin<div>UniProt AccessionID: P35169</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#fcf49745-88e3-40e2-99cd-c9b7b890ef41">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:14673167"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_8e40171a-4e56-4b77-b613-b0ce9231c89f" qual:compartment="cytosol" qual:constant="false" qual:id="S_65" qual:initialLevel="0" qual:maxLevel="1" qual:name="HOG1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>High osmolarity glycerol response<div>UniProt AccessionID: Q03213</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_8e40171a-4e56-4b77-b613-b0ce9231c89f">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-07-17T15:49:48Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:11923319"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_4b5343ce-8214-4590-8313-0ff812b4550e" qual:compartment="cytosol" qual:constant="false" qual:id="S_67" qual:initialLevel="0" qual:maxLevel="1" qual:name="SNO1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>SNZ proximal open reading frame<div>UniProt AccessionID: Q03144</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_4b5343ce-8214-4590-8313-0ff812b4550e">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:56:06Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="e5b5842a-f789-46bd-8fe1-ae9e888f6847" qual:compartment="cytosol" qual:constant="false" qual:id="S_68" qual:initialLevel="0" qual:maxLevel="1" qual:name="NMA111-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Nuclear mediator of apoptosis in nucleus<div><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 14.399999618530273px; background-color: rgb(255, 255, 255);">UniProt AccessionID: P53920</span></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#e5b5842a-f789-46bd-8fe1-ae9e888f6847">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:16608876"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="d501d26d-e77e-4d0a-a5e5-1d013308a180" qual:compartment="cytosol" qual:constant="false" qual:id="S_69" qual:initialLevel="0" qual:maxLevel="1" qual:name="FVY10">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Function required for yeast viability<div>UniProt AccessionID: P40492</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#d501d26d-e77e-4d0a-a5e5-1d013308a180">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2018-04-14T20:56:06Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_39afe857-8aab-4c6d-8207-16ace60a8e2e" qual:compartment="cytosol" qual:constant="false" qual:id="S_70" qual:initialLevel="0" qual:maxLevel="1" qual:name="NUC1-MT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Nuclease 1 in mitochondria<div>UniProt AccessionID: P08466</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_39afe857-8aab-4c6d-8207-16ace60a8e2e">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17244531"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="e05e7cb0-9069-421a-8e3a-cd583639a65b" qual:compartment="cytosol" qual:constant="false" qual:id="S_71" qual:initialLevel="0" qual:maxLevel="1" qual:name="AIF1-NUC">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Apoptosis-inducing factor in nucleus<div>UniProt AccessionID:&nbsp;<a href="http://www.uniprot.org/uniprot/P52923" style="text-decoration: none; font-family: sans-serif; font-size: small; background-color: rgb(255, 255, 255);">P52923</a></div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#e05e7cb0-9069-421a-8e3a-cd583639a65b">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15381687"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="_04a1e3c5-be68-4bcb-8ac2-f4f69e34fb49" qual:compartment="cytosol" qual:constant="false" qual:id="S_72" qual:initialLevel="0" qual:maxLevel="1" qual:name="MT-ALT">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Mitochondria alteration</p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#_04a1e3c5-be68-4bcb-8ac2-f4f69e34fb49">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2015-11-15T17:58:35Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:15381687"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:20075938"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:17453165"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
<qual:qualitativeSpecies metaid="fff9cb92-ecf2-4ee4-96ea-89dd4fb1215c" qual:compartment="cytosol" qual:constant="false" qual:id="S_73" qual:initialLevel="0" qual:maxLevel="1" qual:name="SOD2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><p style="orphans: 3; widows: 3; line-height: 1.5em; margin: 0.4em 0px 0.5em; color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; background-color: rgb(255, 255, 255);"><span id="parentSpecies:viewSpeciesDescription">Superoxide dismutase</span></p><div style="font-size: 12px; color: rgb(79, 79, 79); font-family: Arial, sans-serif; line-height: 14.399999618530273px; background-color: rgb(255, 255, 255);">Uniprot AccessionID: P00447</div></p></body>
</notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Description rdf:about="#fff9cb92-ecf2-4ee4-96ea-89dd4fb1215c">
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2017-05-19T14:00:19Z</dcterms:W3CDTF>
</dcterms:modified>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:23233838"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
</rdf:Description>
</rdf:RDF>
</annotation>
</qual:qualitativeSpecies>
</qual:listOfQualitativeSpecies>
<qual:listOfTransitions xmlns:qual="http://www.sbml.org/sbml/level3/version1/qual/version1">
<qual:transition qual:id="tr_S_1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Heat positively regulates NMA111-CYT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_1_in_S_59" qual:qualitativeSpecies="S_59" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Heat positively regulates NMA111-CYT {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_1" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_59 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_2">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates ESP1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_2_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates ESP1 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_2" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_3">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Stress positively regulates RPD3</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_3_in_S_36" qual:qualitativeSpecies="S_36" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Stress positively regulates RPD3 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_3" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_4">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 20px; text-align: center; background-color: rgb(255, 255, 255);">Abnormal Telomerase positively regulates MEC1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_4_in_S_20" qual:qualitativeSpecies="S_20" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 20px; text-align: center; background-color: rgb(255, 255, 255);">Abnormal Telomerase positively regulates MEC1 {[1][2]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_4" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_20 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_5">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>SLT2 &nbsp;protein is independently activated by Heat [1,2] and RLM1 [1,2]. PTP2, SDP1, and Stress all individually inhibit activation of SLT2 protein [1,2]</p><p>PTP2, SDP1, and Stress are listed as positive regulators with certain conditions in order to get equivalent behavior to the original expression SLT2 =(!PTP2) OR (!SDP1) OR (!Stress) OR (Heat) OR (RLM1).</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_5_in_S_37" qual:qualitativeSpecies="S_37" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*SDP1 negatively regulates SLT2 {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_5_in_S_52" qual:qualitativeSpecies="S_52" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*PTP2 negatively regulates SLT2 {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_5_in_S_59" qual:qualitativeSpecies="S_59" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Heat positively regulates SLT2 {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_5_in_S_36" qual:qualitativeSpecies="S_36" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Stress negatively regulates SLT2 {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_5_in_S_61" qual:qualitativeSpecies="S_61" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-size: 10pt;">*RLM1 forms a feedback loop to trigger activation of SLT2 and PTP2 {[1]-p.4}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_5" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_37 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_59 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_37 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_37 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_61 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_37 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_59 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_61 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_6">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Mating pheromone positively regulates MAPK</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_6_in_S_48" qual:qualitativeSpecies="S_48" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Mating pheromone positively regulates MAPK {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_6" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_48 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_7">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*STE20-CYT positively regulates STE20-NUC</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_7_in_S_9" qual:qualitativeSpecies="S_9" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*STE20-CYT positively regulates STE20-NUC {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_7" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_9 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_8">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MDV1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_8_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MDV1 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_8" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_9">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MAPK positively regulates STE20-CYT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_9_in_S_6" qual:qualitativeSpecies="S_6" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MAPK positively regulates STE20-CYT {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_9" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_6 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_11">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates POR1-2</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_11_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates POR1-2 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_11" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_12">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Adozelesin positively regulates CDC6</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_12_in_S_63" qual:qualitativeSpecies="S_63" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Adozelesin positively regulates CDC6 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_12" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_63 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_13">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOG1 positively regulates HOG1-Dep</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_13_in_S_65" qual:qualitativeSpecies="S_65" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOG1 positively regulates HOG1-Dep {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_13" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_65 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_15">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates EMC4</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_15_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates EMC4 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_15" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_16">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AIF1-NUC positively regulates H2B</p><p>*HOS3 positively regulates H2B</p><p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*NUC1-NUC positively regulates H2B</span></p><p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*RPD3 positively regulates H2B </span></p><p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*STE20-NUC positively regulates H2B</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_16_in_S_3" qual:qualitativeSpecies="S_3" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*RPD3 positively regulates H2B {[1][6]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_16_in_S_71" qual:qualitativeSpecies="S_71" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AIF1-NUC positively regulates H2B {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_16_in_S_35" qual:qualitativeSpecies="S_35" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*NUC1-NUC positively regulates H2B {[1][5]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_16_in_S_41" qual:qualitativeSpecies="S_41" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOS3 positively regulates H2B {[1][4]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_16_in_S_7" qual:qualitativeSpecies="S_7" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*STE20-NUC positively regulates H2B {[1][3]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_16" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_41 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_7 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_71 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_3 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_35 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_17">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*FIS1 negatively regulates MT-Frag</span></p><p>*DRE2_TAH18 negatively regulates MT-Frag</p><p>*MT-ALT positively regulates MT-Frag</p><p>*H2O2 positively regulates MT-Frag</p><p>*MDV1 positively regulates MT-Frag</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_17_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates MT-Frag {[1][3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_17_in_S_72" qual:qualitativeSpecies="S_72" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MT-ALT positively regulates MT-Frag {[1]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_17_in_S_25" qual:qualitativeSpecies="S_25" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*DRE2_TAH18 negatively regulates MT-Frag {[1][3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_17_in_S_30" qual:qualitativeSpecies="S_30" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*FIS1 negatively regulates MT-Frag {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_17_in_S_8" qual:qualitativeSpecies="S_8" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MDV1 positively regulates MT-Frag {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_17" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_25 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_8 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_30 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_72 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_18">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates CDC48</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_18_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates CDC48 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_18" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_19">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Heat positively regulates SOD1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_19_in_S_59" qual:qualitativeSpecies="S_59" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Heat positively regulates SOD1 {[1]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_19" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_59 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_21">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MMI1 </span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_21_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MMI1 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_21" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_22">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Acetic Acid positively regulates CytC-MT</p><p>*MCD1-MT positively regulates CytC-MT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_22_in_S_33" qual:qualitativeSpecies="S_33" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MCD1-MT positively regulates CytC-MT {[1] [3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_22_in_S_14" qual:qualitativeSpecies="S_14" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Acetic Acid positively regulates CytC-MT {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_22" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_33 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_23">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Heat and RAS2 both independently positively regulate PKA [1,2,3].</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_23_in_S_31" qual:qualitativeSpecies="S_31" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*RAS2 positively regulates PKA {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_23_in_S_59" qual:qualitativeSpecies="S_59" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><div><span style="font-size: 10pt;">*Heat positively regulates PKA {[1][3]}</span></div></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_23" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_31 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_59 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_24">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOG1-Dep positively regulates PTP3</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_24_in_S_13" qual:qualitativeSpecies="S_13" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOG1-Dep positively regulates PTP3 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_24" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_13 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_25">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates DRE2_TAH18</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_25_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates DRE2_TAH18 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_25" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_26">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CDC6 positively regulates Protosom complex</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_26_in_S_12" qual:qualitativeSpecies="S_12" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CDC6 positively regulates Protosom complex {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_26" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_12 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_27">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates SVF1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_27_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates SVF1 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_27" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_28">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CDC48 positively regulates CytC-CYT</p><p>CytC-MT positively regulates CytC-CYT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_28_in_S_18" qual:qualitativeSpecies="S_18" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CDC48 positively regulates CytC-CYT {[1] [2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_28_in_S_22" qual:qualitativeSpecies="S_22" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>CytC-MT positively regulates CytC-CYT {[1] [2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_28" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_22 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_18 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_29">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MG2 positively regulates Tat-D</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_29_in_S_34" qual:qualitativeSpecies="S_34" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MG2 positively regulates Tat-D {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_29" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_34 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_30">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Housekeeping positively regulates FIS1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_30_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Housekeeping positively regulates FIS1 {[1]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_30" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_31">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*RedActinDyn positively regulates RAS2</p><p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*TOR1 positively regulates RAS2 </span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_31_in_S_64" qual:qualitativeSpecies="S_64" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*TOR1 positively regulates RAS2 {[1][3]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_31_in_S_53" qual:qualitativeSpecies="S_53" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*RedActinDyn positively regulates RAS2 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_31" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_53 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_64 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_33">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MCD1-MT</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_33_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates MCD1-MT {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_33" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_35">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*KAP123 positively regulates NUC1-NUC</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_35_in_S_57" qual:qualitativeSpecies="S_57" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*KAP123 positively regulates NUC1-NUC {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_35" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_57 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_37">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MSN2-4 positively regulates SDP1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_37_in_S_47" qual:qualitativeSpecies="S_47" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MSN2-4 positively regulates SDP1 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_37" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_47 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_38">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SLT2 negatively regulates DesCyclinCCDK8</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_38_in_S_5" qual:qualitativeSpecies="S_5" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SLT2 negatively regulates DesCyclinCCDK8 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_38" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<not/>
<apply>
<eq/>
<ci> S_5 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_39">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">DNA-Frag positively regulates Apoptosis [1,4].&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">ROS-CYT positively regulates Apoptosis [1,5].&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">CU2 and CPR3 in conjunction positively regulate Apoptosis [1,3].</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">AceticAcid or H202 and not POR1-2 activate Apoptosis [1,6]. YCA1 and not&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">BIR1 regulate Apoptosis [1,7].</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">FVY10 negatively regulates Apoptosis [1,2].&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">&nbsp;</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">SNO1 negatively regulates Apoptosis [1,2].</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_39_in_S_69" qual:qualitativeSpecies="S_69" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*FVY10 negatively regulates Apoptosis {[1] [2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*POR1-2 negatively regulates Apoptosis in the presence of H202 {[1][6]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_58" qual:qualitativeSpecies="S_58" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CU2 works in conjunction with CPR3 to positively regulate Apoptosis {[1][[3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_40" qual:qualitativeSpecies="S_40" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Overexpression of BIR1 reduces Apoptosis {[1][7]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_11" qual:qualitativeSpecies="S_11" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*POR1-2 negatively regulates Apoptosis in the presence of AceticAcid {[1][6]}</span><div>*POR1-2 negatively regulates Apoptosis in the presence of H202 {[1][6]}</div></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_44" qual:qualitativeSpecies="S_44" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*ROS-CYT positively regulates Apoptosis {[1][5]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_67" qual:qualitativeSpecies="S_67" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SNO1 negatively regulates Apoptosis {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_51" qual:qualitativeSpecies="S_51" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*CU2 works in conjunction with CPR3 to positively regulate Apoptosis {[1][[3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_14" qual:qualitativeSpecies="S_14" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Acetic Acid acts as an indirect inducer of Apoptosis {[1][6][7]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_54" qual:qualitativeSpecies="S_54" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Apoptosis is Y-cal1p dependent {[1][7][8][9]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_39_in_S_43" qual:qualitativeSpecies="S_43" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*DNA-Frag positively regulates Apoptosis {[1][4]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_39" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_43 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_58 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_54 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_44 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_43 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<and/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_44 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_54 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_43 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_51 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<eq/>
<ci> S_58 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<and/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_44 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<not/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_69 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_58 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_40 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_11 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_44 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_67 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_51 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_54 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_43 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_40">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*</span><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; orphans: 3; widows: 3; line-height: 20px; text-align: center; background-color: rgb(255, 255, 255);">NMA111-NUC negatively regulates BIR1 [1,2]</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_40_in_S_68" qual:qualitativeSpecies="S_68" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 20px; text-align: center; background-color: rgb(255, 255, 255);">NMA111-NUC inactivates BIR1 {[1][2]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_40" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<not/>
<apply>
<eq/>
<ci> S_68 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_41">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates HOS3</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_41_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates HOS3 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_41" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_42">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>NDI1 positively regulates ROS-MT in the absence of SOD2</p><p>NDI1 positively regulates ROS-MT in the absence of SOD2</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_42_in_S_55" qual:qualitativeSpecies="S_55" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>NDI1 positively regulates ROS-MT in the absence of SOD2 {[1] [2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_42_in_S_73" qual:qualitativeSpecies="S_73" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>NDI1 positively regulates ROS-MT in the absence of SOD2 {[1] [2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_42" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<and/>
<apply>
<eq/>
<ci> S_55 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_73 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_43">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>Tat-D activates DNA-frag [1,2]. STM1-NUC deactivates DNA-Fra [1,3].</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_43_in_S_49" qual:qualitativeSpecies="S_49" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*STM1-NUC negatively regulates DNA-Frag {[1][3]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_43_in_S_29" qual:qualitativeSpecies="S_29" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Tat-D positively regulates DNA-Frag {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_43" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_29 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_49 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_29 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_44">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">CDC48 , DesCyclinCCDK8 [3], ESP1 [6], RAS2 [2], and NDI1 independently positively regulate ROS-CYT [1].&nbsp;</span>ROS-CYT is negatively regulated by SVF1 in the&nbsp;<span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">presence of H2O2 or Acetic Acid [1,7]. ROS-CYT is negatively regulated by EMC4 when in the presence of H2O2 [1,4].</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_44_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*EMC4 negatively regulates ROS-CYT in the presence of H2O2 {[1][4]}</span><div>*SVF1 negatively regulates ROS-CYT&nbsp;<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">in the presence of H2O2 or Acetic Acid {[1][7]}</span></div></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_38" qual:qualitativeSpecies="S_38" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*DesCyclinCCDK8</span><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">&nbsp;positively regulates ROS-CYT {[1][3]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_31" qual:qualitativeSpecies="S_31" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*RAS2 positively regulates ROS-CYT {[1] [2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_66" qual:qualitativeSpecies="S_66" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Salt positively regulates ROS-CYT {[1][5]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_18" qual:qualitativeSpecies="S_18" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Two occurrences of CDC48 positively regulates ROS-CYT {[1]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_55" qual:qualitativeSpecies="S_55" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Two occurrences of NDI1 positively regulates ROS-CYT {[1]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_27" qual:qualitativeSpecies="S_27" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SVF1 negatively regulates ROS-CYT&nbsp;<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">in the presence of H2O2 or Acetic Acid {[1][7]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_53" qual:qualitativeSpecies="S_53" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*RedActinDyn positively regulates ROS-CYT {[1] [8]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_19" qual:qualitativeSpecies="S_19" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*SOD2 positively regulates ROS-CYT {[1][8]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_15" qual:qualitativeSpecies="S_15" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*EMC4 negatively regulates ROS-CYT in the presence of H2O2 {[1][4]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_2" qual:qualitativeSpecies="S_2" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*ESP1 positively regulates ROS-CYT {[1] [6]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_44_in_S_14" qual:qualitativeSpecies="S_14" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SVF1 negatively regulates ROS-CYT&nbsp;<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">in the presence of H2O2 or Acetic Acid {[1][7]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_44" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_31 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_55 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_66 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_2 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_15 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_53 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_38 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_27 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_14 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_27 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_19 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_18 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_45">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates AIF1-MT</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_45_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Housekeeping positively regulates AIF1-MT {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_45" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_46">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AdenylateCyclase positively regulates cAMP</p><p>*TOR1 positively regulates cAMP</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_46_in_S_64" qual:qualitativeSpecies="S_64" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*TOR1 positively regulates cAMP {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_46_in_S_62" qual:qualitativeSpecies="S_62" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AdenylateCyclase positively regulates cAMP {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_46" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_64 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_62 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_47">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>PKA positively regulates MSN2-4.</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_47_in_S_23" qual:qualitativeSpecies="S_23" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*When heat shock inhibits activity to PKA, the inhibition effect PKA has on MSN2-4 is released.<span style="font-size: 10pt;">{[1]-p.5, [2]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_47" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_23 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_49">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Protosom negatively regulates STM1-NUC in the presence of STM1-CYT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_49_in_S_60" qual:qualitativeSpecies="S_60" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Protosom negatively regulates STM1-NUC in the presence of STM1-CYT {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_49_in_S_26" qual:qualitativeSpecies="S_26" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Protosom negatively regulates STM1-NUC in the presence of STM1-CYT {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_49" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<and/>
<apply>
<eq/>
<ci> S_60 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_26 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_50">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*ESP1 positively regulates MDC1-NUC</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_50_in_S_2" qual:qualitativeSpecies="S_2" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*ESP1 positively regulates MDC1-NUC {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_50" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_2 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_52">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>The PTP2 protein is positively regulated by RLM1 [1,2].</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_52_in_S_61" qual:qualitativeSpecies="S_61" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-size: 10pt;">*RLM1 forms a feedback loop to trigger activation of SLT2 and PTP2 {[1]-p.4}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_52" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_61 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_54">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*CytC-CYT positively regulates YCA1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_54_in_S_56" qual:qualitativeSpecies="S_56" qual:sign="negative" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SRO7 negatively regulates YCA1 in the presence of Salt {[1] [4]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_17" qual:qualitativeSpecies="S_17" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*MT-Frag positively regulates YCA1 {[1] [6]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_66" qual:qualitativeSpecies="S_66" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*SRO7 negatively regulates YCA1 in the presence of Salt {[1] [4]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_53" qual:qualitativeSpecies="S_53" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*RedActinDyn positively regulates YCA1 {[1] [2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_44" qual:qualitativeSpecies="S_44" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*ROS-CYT positively regulates YCA1 {[1] [2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_28" qual:qualitativeSpecies="S_28" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*CytC-CYT positively regulates YCA1 {[1] [6]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_54_in_S_4" qual:qualitativeSpecies="S_4" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*MEC1 positively regulates YCA1 {[1] [3]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_54" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_44 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_4 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_28 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_53 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_66 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_56 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_17 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_55">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates NDI1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_55_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates NDI1 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_55" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_56">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SRO7</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_56_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SRO7 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_56" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_57">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*NUC1-MT positively regulates KAP123</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_57_in_S_70" qual:qualitativeSpecies="S_70" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*NUC1-MT positively regulates KAP123 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_57" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_70 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_60">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates STM1-CYT</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_60_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates STM1-CYT {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_60" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_61">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>HOG1 and SLT2 independently activate RLM1 [1,2]</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_61_in_S_65" qual:qualitativeSpecies="S_65" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*HOG1 positively regulates RLM1 {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_61_in_S_5" qual:qualitativeSpecies="S_5" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*SLT2 positively regulates RLM1 {[1][2]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_61" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_5 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_65 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_62">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3;">*RAS2 positively regulates Adenylate Cyclase</span></p><p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Stress negatively regulates Adenylate Cyclase</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_62_in_S_31" qual:qualitativeSpecies="S_31" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3;">*RAS2 positively regulates Adenylate Cyclase {[2][3]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_62_in_S_36" qual:qualitativeSpecies="S_36" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*Stress negatively regulates Adenylate Cyclase {[1][3]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_62" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<eq/>
<ci> S_31 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_64">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Stress positively regulates TOR1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_64_in_S_36" qual:qualitativeSpecies="S_36" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Stress positively regulates TOR1 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_64" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_65">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">PTP2 negatively regulates HOG1</span></p><p>*PTP3 negatively regulates HOG1</p><p>*Stress positively regulates HOG1</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_65_in_S_52" qual:qualitativeSpecies="S_52" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*<span style="font-family: Arial, sans-serif; font-size: 12px; line-height: 24px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">PTP2 negatively regulates HOG1 {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_65_in_S_24" qual:qualitativeSpecies="S_24" qual:sign="dual" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*PTP3 negatively regulates HOG1 {[1][2]}</p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_65_in_S_36" qual:qualitativeSpecies="S_36" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Stress positively regulates HOG1 {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_65" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<and/>
<apply>
<eq/>
<ci> S_24 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<and/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<not/>
<apply>
<eq/>
<ci> S_24 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<not/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_52 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_24 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_36 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_67">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SNO1</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_67_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SNO1 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_67" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_68">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*NMA111-CYT positively regulates NMA111-NUC</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_68_in_S_1" qual:qualitativeSpecies="S_1" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="color: rgb(79, 79, 79); font-family: Arial, sans-serif; font-size: 12px; line-height: 18px; orphans: 3; widows: 3; background-color: rgb(255, 255, 255);">*NMA111-CYT positively regulates NMA111-NUC {[1][2]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_68" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_1 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_69">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Housekeeping positively regulates FVY10</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_69_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*Housekeeping positively regulates FVY10 {[1]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_69" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_70">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates NUC1-MT</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_70_in_S_10" qual:qualitativeSpecies="S_10" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*H2O2 positively regulates NUC1-MT {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_70" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_10 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_71">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AIF1-MT positively regulates AIF1-NUC</p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_71_in_S_45" qual:qualitativeSpecies="S_45" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*AIF1-MT positively regulates AIF1-NUC {[1][2]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_71" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_45 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_72">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MMI1 positively regulates MT-ALT</p><p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*MT-Frag positively regulates MT-ALT</span></p><p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*PKA positively regulates MT-ALT</span></p><p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*RAS2 positively regulates MT-ALT</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_72_in_S_17" qual:qualitativeSpecies="S_17" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*MT-Frag positively regulates MT-ALT {[1][2]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_72_in_S_23" qual:qualitativeSpecies="S_23" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*PKA positively regulates MT-ALT {[1] [3]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_72_in_S_31" qual:qualitativeSpecies="S_31" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*RAS2 positively regulates MT-ALT {[1] [4]}</span></p></body>
</notes>
</qual:input>
<qual:input qual:id="tr_S_72_in_S_21" qual:qualitativeSpecies="S_21" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p>*MMI1 positively regulates MT-ALT {[1] [4]}</p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_72" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<or/>
<apply>
<or/>
<apply>
<or/>
<apply>
<eq/>
<ci> S_21 </ci>
<cn type="integer"> 1 </cn>
</apply>
<apply>
<eq/>
<ci> S_17 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_31 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
<apply>
<eq/>
<ci> S_23 </ci>
<cn type="integer"> 1 </cn>
</apply>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
<qual:transition qual:id="tr_S_73">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SOD2</span></p></body>
</notes>
<qual:listOfInputs>
<qual:input qual:id="tr_S_73_in_S_32" qual:qualitativeSpecies="S_32" qual:sign="positive" qual:thresholdLevel="1" qual:transitionEffect="none">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<p><span style="LINE-HEIGHT: 24px; WIDOWS: 3; BACKGROUND-COLOR: rgb(255,255,255); FONT-FAMILY: Arial, sans-serif; ORPHANS: 3; FONT-SIZE: 12px">*Housekeeping positively regulates SOD2 {[1]}</span></p></body>
</notes>
</qual:input>
</qual:listOfInputs>
<qual:listOfOutputs>
<qual:output qual:qualitativeSpecies="S_73" qual:transitionEffect="assignmentLevel"/>
</qual:listOfOutputs>
<qual:listOfFunctionTerms>
<qual:defaultTerm qual:resultLevel="0">
</qual:defaultTerm>
<qual:functionTerm qual:resultLevel="1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> S_32 </ci>
<cn type="integer"> 1 </cn>
</apply>
</math>
</qual:functionTerm>
</qual:listOfFunctionTerms>
</qual:transition>
</qual:listOfTransitions>
<listOfCompartments>
<compartment constant="true" id="extracellular" name="extracellular"/>
<compartment constant="true" id="cytosol" name="cytosol"/>
</listOfCompartments>
</model>
</sbml>